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This review does not provide an exhaustive, comprehensive review of the literature

Renal Impairment- TRESIBA pharmacokinetics was studied in 32 subjects (N=4-8/group) with normal or impaired renal function/end-stage renal disease following administration of a single subcutaneous dose (0.4 units/kg) of TRESIBA

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Likewise, disulfidoptosis occurs due to SLC7A11 overexpression leading to excessive cystine uptake and depletion of NADPH, resulting in aberrant actin disulfide bonding, cytoskeletal disruption, and cell death, especially during glucose deprivation (145)